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Cell-Based Bioassays for Biologics

Ready-to-Use Cell-Based Assays for Comparability and QC Lot Release Testing

Pharmaceutical companies are developing an increasing number of biologics, biosimilars and biobetters, thereby creating a need for MOA-reflective cell-based assays that can support multiple stages of the biopharmaceutical development pipeline. DiscoverX offers the largest menu of “Thaw & Use” Bioassay kits that have been qualified with marketed biologic drugs or reference standards. Bioassay kits are also available as target-specific cell-based bioassays that are easy to implement in any lab from development to QC/Lot release.
 

Qualified Bioassays


Thaw-and-use bioassay kits qualified with marketed biologic drugs.

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Target-Based Bioassays


Rapid, robust, and reproducible target-based bioassay kits.

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Custom Bioassays


Request early access to bioassay kits that are currently being qualified.

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Available Targets


Chose from over 750 targets to develop bioassays for your biologics.


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Bioassay Formats

PathHunter® Bioassays are ideal for determining drug potency and stability using a simple and rapid, mix & read protocol that reflects the drug’s clinical mechanism of action.  The Bioassays can be used to detect neutralizing anti-drug antibodies (ADAs) or NAbs in patient serum samples, with high sensitivity and reproducibility. 
 

Potency and Stability


 

Neutralizing Antibodies


 

 

Four Applications of PathHunter Technology for Biologics Development

DiscoverX has exploited the versatile features of enzyme fragment complementation (EFC) technology to create cell-based assays for a vast number of proteins.  PathHunter assays are designed using two inactive fragments of β-galactosidase (β-gal), which combine to create an active enzyme. Click on the images below to learn more about solutions for the specific applications you are interested in.
 

Receptor Activation

Receptor Internalization

Receptor Dimerization

Receptor Signaling

receptor activation Receptor Internalization Receptor Signaling