Cell Lines & Primary Cells

Engineered cell lines are essential for in vitro cell-based assays replicating biological systems' physiology. Cell lines are developed reflecting the target’s mechanism of action (MOA) with a drug interaction in a standard cell line background. Cell lines can be propagated repeatedly and kept in culture for extended periods of time. These cells provide the ability to deliver more physiologically relevant results in a cost-effective manner reproducibly.

Eurofins DiscoverX® provides the most extensive collection of >1,000 fully qualified, functional cell lines that enable unique drug discovery and development solutions at every stage of your program. Cell lines covering all major drug target classes including GPCRs, cytokines, kinases, checkpoint inhibitors, ion channels, and nuclear proteins such as transcription factors, NHRs, and epigenetic proteins.

With over two decades of experience in generating stable cell lines, Eurofins DiscoverX provides cell lines with unsurpassed quality and industry-validated performance. These cell lines have been used to screen billions of data points to help bring many therapeutics to the market, with many more in the pipeline.

Use the appropriate application-specific detection kits with your cell line model for a complete functional cell-based assay to interrogate the MOA of your small molecule or biologic, measure and rank ligands potencies, perform binding and functional screens, implement as a lot release assay, and much more.

Product Highlights
  • Robust Performance – Rigorously and continuously validated for accurate pharmacology through Eurofins Discovery with billions of data points screened
  • Versatile Use – Interrogate diverse MOAs with broad applications ideal for small molecules and biologics screening or profiling
  • Diverse – Select relevant cell models from over 50 cell types such as HEK 293, CHO-K1, U2OS, and more
  • Established – Implemented in 200+ global programs for potency, stability, & NAb testing

Consider Eurofins DiscoverX’s custom development capabilities for custom cell lines, assays, & enzyme development.

SHOP PRODUCTSTARGETS LISTCELL BANKING

Products

  • Stable Cell Lines – Stable cell lines extensively validated with billions of compounds, confirmed stability beyond 10 passages, and usable for a variety of research and drug discovery and development applications
  • KILR® Effector Cells – Single donor-derived human primary cytotoxic T cells to measure target cell death using antibody-dependent cell-mediated cytotoxicity and bi-specific antibody-mediated T Cell Redirection assays for screening, characterization, and QC lot release of antibody drugs. Learn more about KILR Effector Cells.
  • KILR Cell Lines and Pools – Stable cell lines and cell pools to specifically measure target cell death in co-cultures using a simple, non-radioactive, and dye-free method that can be easily implemented in drug discovery through QC lot release programs. Single clonal cell lines include homogeneous expression of a known target protein, while cell pools allow targeting of your protein of interest specific to your immunotherapeutic drug candidate from a variety cell type’s natively expressed cell surface proteins. Learn more about KILR Cytotoxicity Products.
  • GPCR cAMP and Calcium Cells – Ready-to-assay GPCR cryo-preserved cells validated for cAMP accumulation and calcium flux applications and ideal for screening of agonists, antagonists and various modulators. Learn more about GPCR cAMP and Calcium Products.
  • PrecisION™ Ready-to-assay Cells - Simple thaw-and-use frozen cells for quick ion channel electrophysiological assessment without the need for cell culture. Learn more about Ion Channel Products.
  • Parental Cell Lines – Engineered cells to generate your own assays to measure internalization, β-arrestin recruitment, pharmacotrafficking, and translocation assays of your membrane protein of interest, as well as receptor-specific signaling pathway activation