Offering Industry’s Largest Portfolio of Purified Recombinant Proteins for Screening Inhibitors
Recombinant proteins in drug discovery and development are exogenous proteins expressed in a production organism and used for the treatment or prevention of disease in humans or animals. Kinases are cell signaling enzymes that catalyze the transfer of a phosphate group from ATP to its substrate, while phosphatases are regulatory enzymes that remove the phosphate group. Epigenetic proteins modify the structure of DNA or its associated proteins, such as histones, in order to regulate gene expression. These proteins play roles in the regulation of intracellular signaling pathways or modulate epigenetic mechanisms. Ubiquitin proteins perform key roles in protein degradation pathways and cellular processes such as DNA repair, gene expression, and endocytosis.
There are ~538 kinases in the human genome (eLife Sciences, 2021), and they are generally grouped into either serine/threonine, tyrosine, or lipid kinases. Kinase substrates include a variety of intracellular proteins and molecules, including other kinases, transcription factors, lipids, and other proteins. The phosphorylation and dephosphorylation of the substrate modifies its enzymatic activity. These activities include diverse cellular processes, including cell division, protein synthesis, transcriptional regulation, and neurotransmission. Activating mutations of kinases, or their dysregulation by upstream factors, that lead to either gain-of-function or loss-of-function are implicated in many diseases, including cancer.
Eurofins DiscoverX® provides a new home for the original Millipore (Upstate) kinase enzyme portfolio covering over 70% of the active human kinome. View the comprehensive portfolio of over 440 active, mutant, and inactive recombinant kinases available in multiple pack sizes, including bulk sizing, to provide you with scalable options. Dissect the physiological role of kinases and phosphatases, screen for inhibitors, or perform enzymatic kinases or phosphatase activity assays. Access the same proteins used daily in the renowned KinaseProfiler™, PhosphataseProfiler™, and EPIscan services, and receive the quality and confidence that comes with screening hundreds of millions of data points generated over the past several decades.
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