Largest Portfolio of Purified Recombinant Proteins for Screening Inhibitors
Kinases are cell signaling enzymes that catalyze the transfer of a phosphate group from ATP to its substrate, while phosphatases are regulatory enzymes that remove the phosphate group. Both enzyme families play roles in the regulation of intracellular signaling pathways. There are ~535 kinases in the human kinome (eLife Sciences, 2021), and they are generally grouped into either serine/threonine, tyrosine, or lipid kinases. Kinase substrates include a variety of intracellular proteins and molecules, including other kinases, transcription factors, lipids, and other proteins. The phosphorylation and dephosphorylation of the substrate modifies its enzymatic activity. These activities include diverse cellular processes, including cell division, protein synthesis, transcriptional regulation, and neurotransmission. Activating mutations of kinases, or their dysregulation by upstream factors, that lead to either gain-of-function or loss-of-function are implicated in many diseases, including cancer.
Eurofins DiscoverX provides a new home for the original Millipore (Upstate) kinase enzyme portfolio covering over 70% of the kinome. View the comprehensive portfolio of over 420 active, mutant, and inactive recombinant kinases available in multiple pack sizes, including bulk sizing, to provide you with scalable options. Dissect the physiological role of kinases and phosphatases, screen for inhibitors, or perform enzymatic kinases or phosphatase activity assays. Access the same enzymes used daily in the renowned KinaseProfiler™ and PhosphataseProfiler™ services, and receive the quality and confidence that comes with screening 100s of millions of data point generated over the past several decades.
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