High-Quality, Cellular and Biochemical Kinase Assays with Full Human Kinome Coverage
DiscoverX offers accurate, reproducible kinase assays with complete human kinome coverage so you can always find a solution for your kinase target. Our kinase profiling service, KINOMEscan®
,includes an industry-leading set of nearly 500 assays, allowing rapid and efficient determination of kinome-wide potency and selectivity of compounds. By integrating EFC technology with deep kinase knowledge and cell-based assays expertise, we offer a growing menu of cellular, functional assays
to detect activated kinases along with binding assays for compound-target engagement
. When used alone or in combination, these robust assay platforms can be used at all stages of drug discovery and are ideal for identifying highly potent and selective kinase inhibitors.
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Create Your Own RTK Functional, Cell-Based Assays
Watch this 30-minute webinar to learn how to make your own receptor tyrosine kinase (RTK) cell-based assays to analyze RTK function, dimerization, and translocation as well as screening of RTK therapeutics. Cytokine receptors and cytosolic (CTK) cell-based assays are discussed.
Expedite Lead Optimization with Kinase Screening Services
KINOMEscan Kinase Profiling Services
The leading selectivity profiling service for kinase inhibitor drug discovery. Leveraging both our panel of over 480 kinase assays and our kinase inhibitor drug discovery expertise, KINOMEscan provides investigators the benefit of kinome-wide profiling, the flexibility to create personalized screening solutions, and the knowledge to support and inform decision making throughout the kinase drug development continuum.
Robust, Cellular Functional Receptor Kinase Assays
PathHunter® Cell-Based Assays for RTKs and CTKs
Fully optimized, target-validated cell-based kinase assays allow you to study kinase activation, dimerization, receptor internalization, SH2-recruitment, and screen for novel kinase inhibitors of both receptor tyrosine kinase (RTK) and cytosolic tryosine kinase (CTK). Our growing panel of tyrosine kinase assays are available as cell lines, assay ready kits, build-your-own assay tools, or services.
Universal Compound-Target Engagement Cell-Based Assays
InCELL Cell-Based Assays for Intracellular Kinases
InCELL Hunter™ and InCELL Pulse™ cellular compound-target engagement assays provide the ability to create your own assays for intracellular kinases as well as confirm compound cell entry, target binding, screen inhibitors, measure cellular EC50 values, and rank compounds--all in the native cellular environment
Simple Fluorescent Assay for Kinase Profiling and Screening
ADP Accumulation Assay
The ADP Accumulation Assay is a generic, antibody-free, homogeneous assay platform that detects kinase activity by monitoring ATP depletion. Reliably measure phosphotransferase-mediated production of ADP, providing a positive signal that increases in direct proportion to ADP accumulation.
Create Your Own Cell-Based Assays to Study Receptor Tyrosine Kinase Function Watch Webinar
Kinase Broad Profiling and Phenotypic Screening Watch Webinars
InCELL Cellular Compound Target Engagement Watch Webinars
An Expanding Chemogenomic Toolbox Gives Kinome Research a Welcome and Much Needed Boost Read Article
Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays Read Article
The Key to Designing a Kinase Screening Project Read Article
Critical Needs in Cellular Target Engagement Read Article
Kinome-Wide Profiling of Existing Chemical Assets: A Powerful Strategy to Jump-Start New Drug Discovery Programs Read Article
DiscoverX and the SGC Partner to Make an Annotated Collection of >600 Kinase Inhibitors Freely Available Read Article
Brochures and Flyers
Kinase Screening and Profiling Download Flyer
InCELL Target Engagement Assays Download Flyer
PathHunter Protein Translocation Assays Download Flyer
PathHunter MAX Panel Screening and Profiling Services Download Flyer
Kinase Targets View List
Kinase Publications View Publications
Tools and Resources Access Resources
InCELL Pulse Target Engagement Kinase Reference Set Download Booklet
Custom Assay Development Services
Can't find your assay on the menu? We can develop it for you. Learn More
Updated Cell Culture and Handling Procedure. Read Protocol